Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2E,6Z,8E,10E)-N-(2-HYDROXY-2-METHYLPROPYL)DODECA-2,6,8,10-TETRAENAMIDE
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83883-10-7

83883-10-7 structure

83883-10-7 structure

Name: Hydroxy-alpha-sanshool
Chemical Name: alpha-Hydroxy-Sanshool
CAS Number: 83883-10-7
Molecular Formula: C₁₆H₂₅NO₂
Molecular Weight: 263.37500
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2016-04-22 04:48:37
Modify Date: 2024-01-20 16:13:45
Hydroxy-α-sanshool is an alkylamide isolated from pepper, acts as a TRPA1 covalent and TRPV1 non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively[1].

Name	alpha-Hydroxy-Sanshool
Synonyms	(2E,6Z,8E,10E)-N-(2-HYDROXY-2-METHYL-PROPYL)DODECA-2,6,8,10-TETRAENAMIDE (2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide

Description	Hydroxy-α-sanshool is an alkylamide isolated from pepper, acts as a TRPA1 covalent and TRPV1 non-covalent agonist, with EC50s of 69 and 1.1 µM, respectively[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	EC50: 69 µM (TRPA1), 1.1 µM (TRPV1)[1]
References	[1]. Koo JY, et al. Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol. 2009 Aug;157(8):1398-409.

Density	0.973 g/cm3
Boiling Point	471.5±45.0℃ at 760 mmHg
Molecular Formula	C₁₆H₂₅NO₂
Molecular Weight	263.37500
Exact Mass	263.18900
PSA	49.33000
LogP	3.28930
Storage condition	2-8℃

HS Code	2924199090

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%