85443-48-7

85443-48-7 structure

Name: Bencianol
Chemical Name: (2R,3S)-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-3,5,7-triol
CAS Number: 85443-48-7
Molecular Formula: C₂₈H₂₂O₆
Molecular Weight: 454.47100
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-20 15:16:49
Modify Date: 2025-08-27 07:54:31
Bencianol is a the semisynthetic flavinoid, with anti-spasmogenic activities.

Name	(2R,3S)-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-3,5,7-triol
Synonyms	UNII-C4A4TVM56F EINECS 287-240-1 Bencianolum Bencianol

Description	Bencianol is a the semisynthetic flavinoid, with anti-spasmogenic activities.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Bencianol causes a dose-related (1-100 μg/mL) reversal of contractions induced by 5-hydroxytryptamine, nor-adrenaline, angiotensin II, prostaglandin F2a, and U-46619 (a thromboxane-A2 mimetic). Bencianol is more effective against contractions induced by EC50 compared to maximal concentrations of each agent, and is least effective against the thromboxane-A2 mimetic, U-46619[1]. Bencianol (0.1-100 nM) produces cytoprotective effects against CCl4 induced cell injury on the above three parameters[2].
References	[1]. Whalley ET, et al. Anti-spasmogenic effects of bencianol (ZY15051) on human cerebral arteries in vitro. Cephalalgia. 1985 Dec;5(4):217-21. [2]. Maignan MF, et al. Cytoprotective effects of Bencianol on porcine vascular endothelial cells in vitro. J Submicrosc Cytol. 1986 Jan;18(1):47-51.