4089-36-5

4089-36-5 structure

Name: dexamethasone oxetanone
Chemical Name: (8S,10S,11S,13S,14S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethylspiro[6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17,2'-oxetane]-3,3'-dione
CAS Number: 4089-36-5
Molecular Formula: C₂₂H₂₇FO₄
Molecular Weight: 374.44600
Catalog: Research Areas Endocrinology
Create Date: 2016-04-10 23:01:06
Modify Date: 2024-01-16 17:22:54
Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].

Name	(8S,10S,11S,13S,14S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethylspiro[6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17,2'-oxetane]-3,3'-dione
Synonyms	Dexamethasone oxetanone

Description	Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology
In Vitro	Dexamethasone oxetanone (1 μM) exhibits significant quantities of agonist activity with transfected PR in CV-1 cells[2].
References	[1]. D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25(3):315-22. [2]. G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 2001 Feb;15(2):255-70.