3',5'-Di-O-benzoyl fialuridine

Names

[ CAS No. ]:
97614-45-4

[ Name ]:
3',5'-Di-O-benzoyl fialuridine

[Synonym ]:
3',5'-Di-O-benzoyl Fialuridine
3 inverted exclamation mark,5 inverted exclamation mark-Di-O-benzoyl-1-(2-deoxy-2-fluoro-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione
3 inverted exclamation mark,5 inverted exclamation mark-Di-O-benzoyl-1-(2'-deoxy-2'-fluoro-D-arabinofuranosyl)-5-iodouracil

Biological Activity

[Description]:

3',5'-Di-O-benzoyl fialuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H18FIN2O7

[ Molecular Weight ]:
580.30

[ Exact Mass ]:
580.01400

[ PSA ]:
116.95000

[ LogP ]:
2.87160

Precursor & DownStream

Precursor

DownStream

Related Compounds

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