Delta (Phospho) Sleep Inducing Peptide
Names
[ CAS No. ]:
70754-23-3
[ Name ]:
Delta (Phospho) Sleep Inducing Peptide
[Synonym ]:
L-Tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-O-phosphono-L-serylglycyl-L-glutamic acid
L-Glutamic acid, L-tryptophyl-L-alanylglycylglycyl-L-α-aspartyl-L-alanyl-O-phosphono-L-serylglycyl-
Biological Activity
[Description]:
Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats[1][2][3].
[Related Catalog]:
[In Vitro]
Delta (Phospho) Sleep Inducing Peptide (20-300 nM) increases rat pineal N-acetyltransferase (NAT) activity induced by norepinephrine in vitro[3].
[In Vivo]
Delta (Phospho) Sleep Inducing Peptide (0.1 nmol/kg; i.v.; once daily for 4 times) induces changes in the circadian locomotor behavior[1]. Delta (Phospho) Sleep Inducing Peptide (20 or 200 pmol/kg; inject into the 3rd cerebroventricle of male rats immediately before the onset of the dark period) increases slow-wave sleep and paradoxical sleep during the subsequent dark period without shortening sleep latency at a dose of 200 pmol/kg[2]. Animal Model: Female rats from own inbred strain (KBS/K60)[1] Dosage: 0.1 nmol/kg Administration: Intravenous injection; once daily for 4 consecutive days Result: Induced rapid and mark changes in the circadian locomotor behavior when during the light (sleeping) phase testing animals became relatively more active.
[References]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Molecular Formula ]:
C35H49N10O18P
[ Molecular Weight ]:
928.794
[ Exact Mass ]:
928.296387
[ LogP ]:
-4.17
[ Index of Refraction ]:
1.614