HBK

Names

[ CAS No. ]:
51025-85-5

[ Name ]:
HBK

[Synonym ]:
AHB-DKB
HBK
HABA-DKB
MFCD00864919
4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide
(S)-O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythrohexopyranosyl-(1®4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine
3-AMINO-2-METHOXY-4-PICOLINE
1-N-[(S)-4-Amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B
Haberacin
Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-
Arbekacin
1-N-[(S)-4-Amino-2-hydroxybutyryl]dibekacin

Biological Activity

[Description]:

Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Arbekaci 有效抑制鲍氏不动杆菌 (MIC50=2 μg/mL) 和来自 PHP 的肠杆菌科 (MIC50=0.25-2 μg/mL; MIC90=1-8 μg/mL)[1]。 Arbekacin 也抑制全球范围内特征明确的耐多药革兰氏阴性和 MRSA 菌株[1]。

[References]

[1]. Matsumoto T. Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens. Clin Pharmacol. 2014 Sep 26;6:139-48.  

[2]. Sader HS, et al. Arbekacin activity against contemporary clinical bacteria isolated from patients hospitalized with pneumonia. Antimicrob Agents Chemother. 2015;59(6):3263-70.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
904.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H44N6O10

[ Molecular Weight ]:
552.619

[ Flash Point ]:
500.5±34.3 °C

[ Exact Mass ]:
552.311890

[ PSA ]:
297.27000

[ LogP ]:
-4.00

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.635


Related Compounds

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