2-(4-dimethylaminostyryl)-1-ethylpyridinium iodide

Names

[ Name ]:
2-(4-dimethylaminostyryl)-1-ethylpyridinium iodide

[Synonym ]:
GNF-Pf-1399
2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide
GNF-Pf-4643
4-[2-(1-ethylpyridin-1-ium-2-yl)ethenyl]-N,N-dimethylaniline,iodide
GNF-Pf-2708
MFCD00011994
EINECS 223-248-3

Biological Activity

[Description]:

DASPEI is a fluorescent dye. DASPEI is a styryl dye that stains mitochondria of live cells. DASPEI has a large fluorescence Stokes shift and is taken up relatively slowly as a function of membrane potential[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. E M Leise. Selective retention of the fluorescent dye DASPEI in a larval gastropod mollusc after paraformaldehyde fixation. Microsc Res Tech. 1996 Apr 15;33(6):496-500.

Chemical & Physical Properties

[ Melting Point ]:
267ºC (dec.)(lit.)

[ Molecular Formula ]:
C₁₇H₂₁IN₂

[ Molecular Weight ]:
380.26700

[ Exact Mass ]:
380.07500

[ PSA ]:
7.12000

[ LogP ]:
0.23440

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU3971000

CHEMICAL NAME :: Pyridinium, 2-(p-(dimethylamino)styryl)-1-ethyl-, iodide

CAS REGISTRY NUMBER :: 3785-01-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H21-N2.I

MOLECULAR WEIGHT :: 380.30

WISWESSER LINE NOTATION :: T6KJ A2 B1U1R DN1&1 &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02331

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UU3971000

Articles

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.

Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008)

The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-...

Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.

Science 334 , 1372-7, (2011)

Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic f...

The role of efflux systems and the cell envelope in fluorescence changes of the lipophilic cation 2-(4-dimethylaminostyryl)-1-ethylpyridinium in Escherichia coli.

Biochim. Biophys. Acta 1278(2) , 205-12, (1996)

The interaction of the fluorescent dye 2-(4-dimethylaminostyryl)-1-ethlypyridinium cation (DMP+) with cells of Escherichia coli AN120 (uncA) and AS-1 (acrA) was studied to elucidate the role of the en...

Related Compounds

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