AZ7550-d5

Names

[ CAS No. ]:
2719690-99-8

[ Name ]:
AZ7550-d5

Biological Activity

[Description]:

AZ7550-d5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of AZD9291 (HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Research Areas >> Others

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R

[In Vitro]

AZ7550-d5 (化合物 M6) 在人肝微粒体中产生的代谢物相对丰度为 15.58%[1]。

[References]

[1]. Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64(2):925-937.

[2]. Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₆D₅N₇O₂

[ Molecular Weight ]:
490.61

Related Compounds

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