SARS-CoV-2-IN-22

Names

[ CAS No. ]:
2710278-53-6

[ Name ]:
SARS-CoV-2-IN-22

Biological Activity

[Description]:

SARS-CoV-2-IN-22 is a SARS-CoV-2 pseudovirus entry inhibitor with an IC50 value of 16.96 µM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 16.96 µM (SARS-CoV-2)[1]

[In Vitro]

SARS-CoV-2-IN-22 (Compound 9a) effectively blocks the binding of SARS-CoV-2 to the host ACE2 receptor through dual recognition of SARS-CoV-2 spike receptor-binding domain (RBD) and human ACE2. SARS-CoV-2-IN-2 displays no cytotoxicity to normal cells (LO2)[1].

[References]

[1]. Ting Xu, et al. Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors. Bioorg Med Chem. 2022 Aug 1;67:116838.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₄N₂O₃S

[ Molecular Weight ]:
456.56

Related Compounds

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