Tubulin polymerization-IN-22

Names

[ Name ]:
Tubulin polymerization-IN-22

Biological Activity

[Description]:

Tubulin polymerization-IN-22 is a tubulin polymerization inhibitor with an IC50 of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vitro]

Tubulin polymerization-IN-22 (Compound 4u) shows antiproliferative activity against human breast cancer cell line (MCF-7) with an IC50 of 1.47 μM[1]. Tubulin polymerization-IN-22 (Compound 4u) is a tubulin polymerization inhibitor by targeting the Colchicine binding site[1].

[References]

[1]. Guangcheng Wang, et al. Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors. Bioorg Chem. 2020 Nov;104:104265.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₆O₄

[ Molecular Weight ]:
308.33

Related Compounds

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