HSV-1/HSV-2-IN-2

HSV-1/HSV-2-IN-2 is a HSV-1, HSV-2 and VV inhibitor with EC50 values of 6.8, 8.9 and 8.9 µM, respectively. HSV-1/HSV-2-IN-2 shows antiviral activity[1].

Signaling Pathways >> Anti-infection >> HSV

Research Areas >> Infection

HSV-1:6.8 μM (EC50)

HSV-2:8.9 μM (EC50)

HSV-1/HSV-2-IN-2(100 µM, 3-6Days, HEL cell cultures) is effective and nontoxic against HSV-1 (KOS), HSV-2 (G), HSV-1 TK- KOS ACVr and VV at low μM doses[1]. Cell Viability Assay Cell Line: HEL cell cultures Concentration: 100 µM Incubation Time: 3-6 Days Result: Showed nontoxic and effective at 6.8, 8.9, 6.8 and 8.9 µM against HSV-1 (KOS), HSV-2 (G), HSV-1 TK- KOS ACVr and VV, respectively.

[1]. Dizhong Chen et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724.