Corydalmine hydrochloride

Names

[ Name ]:
Corydalmine hydrochloride

Biological Activity

[Description]:

Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

Research Areas >> Neurological Disease

[In Vivo]

Corydalmine hydrochloride is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes[2].

[References]

[1]. Basha SA, Jha RN, Pandey VB, Singh UP. Effect of 1-corydalmine,an Alkaloid Isolated from Corydalis chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007;35(2):69-71.

[2]. Tang X, Di X, Zhong Z, et al. In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes. J Pharm Biomed Anal. 2016;128:98-105.

[3]. Zhou L, Hu Y, Li C, et al. Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1/CXCR2 signaling pathway. Neuropharmacology. 2018;135:34-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄ClNO₄

[ Molecular Weight ]:
377.86

Related Compounds

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