β-Lactamase-IN-7

Names

[ CAS No. ]:
2419903-21-0

[ Name ]:
β-Lactamase-IN-7

Biological Activity

[Description]:

β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with Kis of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Ki: 1.26 μM (VIM-1), 0.54 μM (VIM-4)[1]

[References]

[1]. Legru A, et al. 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity. Eur J Med Chem. 2021;226:113873.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₅N₃S₂

[ Molecular Weight ]:
313.44

Related Compounds

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