Tamrintamab pamozirine

Names

[ CAS No. ]:
2148334-68-1

[ Name ]:
Tamrintamab pamozirine

Biological Activity

[Description]:

Tamrintamab pamozirine (DC-1728001; SC-003; SC-003 ADC) an Antibody-Drug Conjugate (ADC) targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab pamozirine can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab pamozirine can be used in ovarian cancer research.[1].

[Related Catalog]:

Research Areas >> Cancer

[Target]

Dipeptidase 3 (DPEP3, MBD3)[1]


[In Vitro]

Tamrintamab pamozirine can be cleaved to pyrrolobenzodiazepine (PBD) dimers to specifically bind DPep3-expressing cells. After internalization, the release of PBD warheads through degradation of the antibody component lysosome induces cytotoxicity[2].

[In Vivo]

Tamrintamab pamozirine (single dose) induced tumor regression in DPEP3-positive HGSC transplantation models (PDX), including platinum-resistant PDX models. Moreover, the antitumor effect of Tamrintamab pamozirine is mediated by a significant reduction in the frequency of tumor-originating cells (TIC)[2].

[References]

[1]. Martín-Sabroso C, et al. Antibody-Antineoplastic Conjugates in Gynecological Malignancies: Current Status and Future Perspectives. Pharmaceutics. 2021 Oct 15;13(10):1705.  

[2]. Wiedemeyer W R, et al. Abstract NT-113: SC-003, AN ANTIBODY-DRUG CONJUGATE TARGETING DIPEPTIDASE 3, EXHIBITS POTENT ANTI-TUMOR ACTIVITY IN PATIENT-DERIVED XENOGRAFT MODELS OF HIGH GRADE SEROUS OVARIAN CANCER[J]. Clinical Cancer Research, 2019, 25(22_Supplement): NT-113-NT-113.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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