2148334-68-1
2148334-68-1 structure
- Name: Tamrintamab pamozirine
- Chemical Name: Tamrintamab pamozirine
- CAS Number: 2148334-68-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2023-03-05 12:41:10
- Modify Date: 2024-07-17 21:53:32
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Tamrintamab pamozirine (DC-1728001; SC-003; SC-003 ADC) an Antibody-Drug Conjugate (ADC) targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab pamozirine can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab pamozirine can be used in ovarian cancer research.[1].
| Name | Tamrintamab pamozirine |
|---|
| Description | Tamrintamab pamozirine (DC-1728001; SC-003; SC-003 ADC) an Antibody-Drug Conjugate (ADC) targeting to dipeptidase 3 (DPEP3 or MBD3). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab pamozirine can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab pamozirine can be used in ovarian cancer research.[1]. |
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| Related Catalog | |
| Target |
Dipeptidase 3 (DPEP3, MBD3)[1] |
| In Vitro | Tamrintamab pamozirine can be cleaved to pyrrolobenzodiazepine (PBD) dimers to specifically bind DPep3-expressing cells. After internalization, the release of PBD warheads through degradation of the antibody component lysosome induces cytotoxicity[2]. |
| In Vivo | Tamrintamab pamozirine (single dose) induced tumor regression in DPEP3-positive HGSC transplantation models (PDX), including platinum-resistant PDX models. Moreover, the antitumor effect of Tamrintamab pamozirine is mediated by a significant reduction in the frequency of tumor-originating cells (TIC)[2]. |
| References |
| No Any Chemical & Physical Properties |