ODN 105871

Names

[ CAS No. ]:
1965342-41-9

[ Name ]:
ODN 105871

Biological Activity

[Description]:

ODN 105871, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105871 can be uesd for inflammatory immune responses research[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

[In Vitro]

ODN 105871 potently inhibits the TLR7-induced TNF-α response in bone marrow-derived macrophages (BMDMs)[1]. In case of Imiquimod-stimulated B cells, ODN 105871 reduces the ATP content to the pretreatment level[1].

[References]

[1]. Franziska Römmler, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.