LY 295427
Names
[ CAS No. ]:
152755-31-2
[ Name ]:
LY 295427
[Synonym ]:
[4α,5α]-4-(2-propenyl)cholestan-3α-ol
(3α,4α,5α)-4-(2-propenyl)cholestan-3-ol
(3R,4S,5S,8S,9S,10R,13R,14S,17R)-4-Allyl-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-ol
Biological Activity
[Description]:
LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3].
[Related Catalog]:
[In Vitro]
LY 295427 时间依赖性地增加中国仓鼠卵巢 (CHO) 细胞对 25-OH chol 的摄取[1]。 LY 295427 (2.9 μM) 提高 30% LDL 受体启动子的活性[2]。
[In Vivo]
LY 295427 剂量依赖性地降低胆固醇-椰子油喂养的仓鼠 LDL-R 转录水平,ED50 值为 40 mg/kg/day[3]。
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C30H52O
[ Molecular Weight ]:
428.73300
[ Exact Mass ]:
428.40200
[ PSA ]:
20.23000
[ LogP ]:
8.27080