Tos-PEG12-Tos

Names

[ CAS No. ]:
1456708-45-4

[ Name ]:
Tos-PEG12-Tos

[Synonym ]:
MFCD28334513
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diyl bis(4-methylbenzenesulfonate)
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diol, bis(4-methylbenzenesulfonate)

Biological Activity

[Description]:

Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
833.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H62O17S2

[ Molecular Weight ]:
855.019

[ Flash Point ]:
457.8±34.3 °C

[ Exact Mass ]:
854.342834

[ LogP ]:
-0.88

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.507

Related Compounds