IDO-IN-5

Names

[ CAS No. ]:
1402837-79-9

[ Name ]:
IDO-IN-5

[Synonym ]:
5H-Imidazo[5,1-a]isoindole-5-ethanol, 6-fluoro-α-(trans-4-hydroxycyclohexyl)-, (αR,5R)-
trans-4-{(1R)-2-[(5R)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexanol
IDO-IN-5

Biological Activity

[Description]:

IDO-IN-5 (NLG-1489) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, compound 1489, has an IC50 of 1-10 μM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Cancer

[Target]

IDO:1-10 μM (IC50)


[In Vitro]

IDO-IN-5 (Compound 1487) is an indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 1-10 μM (this is the concentration of IDO-IN-5 at which inhibits 50% of enzymatic activity using recombinant human IDO)[1].

[References]

[1]. Mario Mautino, et al. Fused imidazole derivatives useful as ido inhibitors. WO 2012142237 A1.


[Related Small Molecules]

Epacadostat(INCB024360) | Indoximod | Linrodostat (BMS-986205) | NLG919 | Coptisine chloride | Navoximod | INCB024360 analogue | PF-06840003 | GNF-PF-3777 | IDO-IN-4 | IDO-IN-1 | IDO-IN-12 | IDO-IN-2 | IDO-IN-3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
555.4±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H21FN2O2

[ Molecular Weight ]:
316.370

[ Flash Point ]:
289.7±25.9 °C

[ Exact Mass ]:
316.158691

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.683

[ Storage condition ]:
2-8℃

Related Compounds