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IDO-IN-6

Names

[ CAS No. ]:
1402837-76-6

[ Name ]:
IDO-IN-6

[Synonym ]:
5H-Imidazo[5,1-a]isoindole-5-ethanol, 6-fluoro-α-(trans-4-hydroxycyclohexyl)-, (αS,5S)-
trans-4-{(1S)-2-[(5S)-6-Fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl}cyclohexanol

Biological Activity

[Description]:

IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Cancer

[Target]

IDO:1 μM (IC50)


[In Vitro]

IDO-IN-6 (Compound 1486) is an indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of <1 μM (this is the concentration of IDO-IN-6 at which inhibits 50% of enzymatic activity using recombinant human IDO)[1].

[References]

[1]. Mautino, et al. Preparation of fused imidazole derivatives as IDO inhibitors. From PCT Int. Appl. (2012), 20121018.


[Related Small Molecules]

Epacadostat(INCB024360) | Indoximod | Linrodostat (BMS-986205) | NLG919 | Coptisine chloride | Navoximod | INCB024360 analogue | PF-06840003 | GNF-PF-3777 | IDO-IN-4 | IDO-IN-1 | IDO-IN-12 | IDO-IN-2 | IDO-IN-3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
555.4±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H21FN2O2

[ Molecular Weight ]:
316.370

[ Flash Point ]:
289.7±25.9 °C

[ Exact Mass ]:
316.158691

[ LogP ]:
1.28

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.683

[ Storage condition ]:
2-8℃

Related Compounds