Azathioprine-13C4

Names

[ Name ]:
Azathioprine-13C4

[Synonym ]:
Azathioprine-13C4
Azanin-13C4
Imurel-13C4
Imurek-13C4
BW-57-322-13C4
Imuran-13C4
Zytrim-13C4
6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine-13C4

Biological Activity

[Description]:

Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Patel, A.A., R.A. Swerlick, and C.O. McCall, Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol, 2006. 55(3): p. 369-89.

[2]. Maltzman, J.S. and G.A. Koretzky, Azathioprine: old drug, new actions. J Clin Invest, 2003. 111(8): p. 1122-4.

[3]. Dubinsky, M.C., Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol, 2004. 2(9): p. 731-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₇N₇O₂S

[ Molecular Weight ]:
281.23300

[ Exact Mass ]:
281.05200

[ PSA ]:
143.40000

[ LogP ]:
1.66900

Related Compounds

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