N-Desethyl amodiaquine-d5 dihydrochloride

Names

[ Name ]:
N-Desethyl amodiaquine-d5 dihydrochloride

[Synonym ]:
Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-[(ethylamino)methyl]-,dihydrochloride (9CI)
[2H5]-Desethylamodiaquine hydrochloride
hloride (5CI)

Biological Activity

[Description]:

N-Desethyl amodiaquine-d5 dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₅Cl₃D₅N₃O

[ Molecular Weight ]:
405.76100

[ Exact Mass ]:
404.09900

[ PSA ]:
57.18000

[ LogP ]:
6.51480

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution