Fraxetin

Names

[ CAS No. ]:
574-84-5

[ Name ]:
Fraxetin

[Synonym ]:
EINECS 209-376-2
6-methoxy-7,8-dihydroxycoumarin
7,8-Dihydroxy-6-methoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one,7,8-dihydroxy-6-methoxy
7,8-Dihydroxy-6-methoxycoumarin
7,8-dihydroxy-6-methoxy-benzopyran-2-one
7,8-Dihydroxy-6-methoxy-2H-1-benzopyran-2-one
Fraxetin
MFCD00006873

Biological Activity

[Description]:

Fraxetin is isolated from Cortex Fraxini. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

[References]

[1]. Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104.

[2]. Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14(6):7374-7378.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
472.0±45.0 °C at 760 mmHg

[ Melting Point ]:
230-232°C

[ Molecular Formula ]:
C₁₀H₈O₅

[ Molecular Weight ]:
208.167

[ Flash Point ]:
196.0±22.2 °C

[ Exact Mass ]:
208.037170

[ PSA ]:
79.90000

[ LogP ]:
0.59

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.648

[ Storage condition ]:
2~8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Studies on chemical constituents from stem barks of Fraxinus paxiana].

Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008)

To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with...

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.

Biochimie 95(10) , 1848-54, (2013)

Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihy...

[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].

Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008)

To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech...

Related Compounds

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