Fraxidin

Names

[ CAS No. ]:
525-21-3

[ Name ]:
Fraxidin

[Synonym ]:
EINECS 208-370-7
8-hydroxy-6,7,-dimethoxycoumarin
8-Hydroxy-6,7-dimethoxy-cumarin
6,7-dimethoxy-8-hydroxy-2H-1-benzopyran-2-one
8-hydroxy-6,7-dimethoxy-2-benzopyrone
6,7-dimethoxy-8-hydroxycoumarin
8-Hydroxy-6,7-dimethoxy-2H-chromen-2-one
Fraxidin
2H-1-Benzopyran-2-one, 8-hydroxy-6,7-dimethoxy-
6,7,8-Trihydroxycoumarin 6,7-dimethyl ether

Biological Activity

[Description]:

Fraxidin is a class of coumarin isolated from the roots of Jatropha podagrica, exhibits antibacterial activity against Bacillus subtilis with an inhibition zone of 12 mm at a concentration of 20 µg/disk[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Bacillus subtilis[2]

[References]

[1]. Kim NY, et al. In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla. Planta Med. 1999 Oct;65(7):656-8.

[2]. Minh TN, et al. Isolation and Purification of Bioactive Compounds from the Stem Bark of Jatropha podagrica. Molecules. 2019 Mar 3;24(5). pii: E889.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
424.2±45.0 °C at 760 mmHg

[ Melting Point ]:
196-197ºC

[ Molecular Formula ]:
C₁₁H₁₀O₅

[ Molecular Weight ]:
222.194

[ Flash Point ]:
171.0±22.2 °C

[ Exact Mass ]:
222.052826

[ PSA ]:
68.90000

[ LogP ]:
0.56

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.588

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%