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Pitavastatin lactone

Names

[ CAS No. ]:
141750-63-2

[ Name ]:
Pitavastatin lactone

[Synonym ]:
2H-Pyran-2-one, 6-[(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-, (4R,6S)-
(4R,6S)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl}-4-hydroxytetrahydro-2H-pyran-2-one
Pitavastatinlactone
Pitavastatin Impurity 4

Biological Activity

[Description]:

Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Fujino H, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
616.9±55.0 °C at 760 mmHg

[ Melting Point ]:
92-95ºC

[ Molecular Formula ]:
C25H22FNO3

[ Molecular Weight ]:
403.445

[ Flash Point ]:
326.9±31.5 °C

[ Exact Mass ]:
403.158386

[ PSA ]:
59.42000

[ LogP ]:
3.44

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.721

Related Compounds