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Pitavastatin calcium

Names

[ CAS No. ]:
147526-32-7

[ Name ]:
Pitavastatin calcium

[Synonym ]:
6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt, (3R,5S,6E)- (2:1)
Pitavastatin Calcium
Livalo
Calcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoate}
MFCD01937979
UNII-IYD54XEG3W
Pitavastatin (Calcium)
calcium,(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
Livazo
(+)-Monocalciumbis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}
(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid
NK-104
[3H]-Pitavastatin
Alipza
Pitavastatin hemicalcium
Nisvastatin
[14C]-Pitavastatin
(+)-Monocalcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}

Biological Activity

[Description]:

Pitavastatin Calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Signaling Pathways >> Autophagy >> Mitophagy
Research Areas >> Metabolic Disease

[References]

[1]. Mukhtar RY, et al. Pitavastatin. Int J Clin Pract. 2005 Feb;59(2):239-52.

[2]. Kajinami K, et al. Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor. Cardiovasc Drug Rev. 2003 Fall;21(3):199-215.


[Related Small Molecules]

3-Methyladenine | SB203580 | U0126-EtOH | Acadesine (AICAR) | Brefeldin A | 17-AAG | Resveratrol | Melatonine | Curcumin | Salinomycin | ABT-737 | Quercetin | Celastrol | Hemin | Torkinib (PP242)

Chemical & Physical Properties

[ Boiling Point ]:
692ºC at 760 mmHg

[ Molecular Formula ]:
C25H23FNO4.1/2Ca

[ Molecular Weight ]:
440.49

[ Flash Point ]:
372.3ºC

[ PSA ]:
186.96000

[ LogP ]:
6.36680

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds