Crocin I

Names

[ Name ]:
Crocin I

[Synonym ]:
Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate
CrocinI
8,8'-Diapo-y,y-carotenedioic acid bis(6-O-b-D-glucopyranosyl-b-D-glucopyranosyl) ester
Digentiobiosyl 8,8'-Diapo-8,8'-carotenedioate
a-Crocin
Crocin I
Gardenia yellow
Kuchinashi yellow
Rikecolor Kuchinashi 20

Biological Activity

[Description]:

Gardenia yellow is an active member of crocin, increases mRNA expression of SIRT3, and acts as an orally active antidepressant agent[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT3

[References]

[1]. Xiao Q, et al. Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice. Physiol Behav. 2019 Oct 12:112699.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1169.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₄H₆₄O₂₄

[ Molecular Weight ]:
976.965

[ Flash Point ]:
337.8±27.8 °C

[ Exact Mass ]:
976.378723

[ PSA ]:
391.20000

[ LogP ]:
-0.83

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.650

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LX2890000

CHEMICAL NAME :: Gardenia Yellow

CAS REGISTRY NUMBER :: 94238-00-3

LAST UPDATED :: 199410

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 mg/plate

REFERENCE :: SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 23,86,1982

Safety Information

[ HS Code ]:
3203001990

Customs

[ HS Code ]: 3203001990