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Terlipressin acetate salt

Names

[ CAS No. ]:
14636-12-5

[ Name ]:
Terlipressin acetate salt

[Synonym ]:
(2S)-1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(Aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl}pyrrolidine-2-carboxamide (non-preferred name)
Terlipressin
EINECS 238-680-8
MFCD00155450
(2S)-1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(Aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxo-2-hexanyl}-2-pyrrolidinecarboxamide
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
Terlipressin Acetate

Biological Activity

[Description]:

Terlipressin is a potent vasoconstrictor that acts via V1 receptors on arteriolar smooth muscle cells. Terlipressin can result in splanchnic vasoconstriction augmenting systemic arterial blood pressure with beneficial circulatory and renal effects that would be expected to also ameliorate the key pathophysiological changes responsible for the development of refractory ascites

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
Research Areas >> Cardiovascular Disease
Peptides

[References]

[1]. Jao YT et al. Refractory torsade de pointes induced by terlipressin (Glypressin). Int J Cardiol, 2016 Jul 30, 222:135-140.


[Related Small Molecules]

Tolvaptan | Mozavaptan | Desmopressin Acetate | Lixivaptan | RO5028442 | OPC 21268 | WAY-151932 | Balovaptan | (Arg8)-Vasotocin acetate salt

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1824.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C52H74N16O15S2

[ Molecular Weight ]:
1227.372

[ Flash Point ]:
1056.9±34.3 °C

[ Exact Mass ]:
1226.496094

[ PSA ]:
563.45000

[ LogP ]:
-6.75

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.664

[ Storage condition ]:
-20°C

Precursor & DownStream

Precursor

DownStream

Related Compounds