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Dehydrotrametenolic acid

Names

[ CAS No. ]:
29220-16-4

[ Name ]:
Dehydrotrametenolic acid

[Synonym ]:
3β-hydroxylanosta-7,9(11)24-trien-21-oic acid
3-epidehydrotrametenolic
3-epi-dehydrotrametenolic acid
3β-hydroxylanosta-7,9(11),24-trien-21-oic acid
3-epidehydrotrametenolic acid
(3β)-3-Hydroxylanosta-7,9(11),24-trien-21-oic acid
Lanosta-7,9(11),24-trien-21-oic acid, 3-hydroxy-, (3β)-
3beta-Hydroxylanosta-7,9(11),24-trien-21-oic acid

Biological Activity

[Description]:

3-​Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-​Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-​Dehydrotrametenolic acid induces apoptosis and has anticancer activity[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[Target]

Lactate dehydrogenase [1]


[References]

[1]. De Nicola GR, et al. Novel gram-scale production of enantiopure R-sulforaphane from Tuscan black kale seeds. Molecules. 2014 May 27;19(6):6975-86.

[2]. Abdull Razis AF, et al. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. Int J Cancer. 2011 Jun 15;128(12):2775-82.

Chemical & Physical Properties

[ Density]:
1.08±0.1 g/cm3

[ Boiling Point ]:
585.4±50.0 °C at 760 mmHg

[ Melting Point ]:
257-259 ºC

[ Molecular Formula ]:
C30H46O3

[ Molecular Weight ]:
454.684

[ Flash Point ]:
321.9±26.6 °C

[ Exact Mass ]:
454.344696

[ PSA ]:
57.53000

[ LogP ]:
8.50

[ Vapour Pressure ]:
0.0±3.7 mmHg at 25°C

[ Index of Refraction ]:
1.557

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Insuluble (1.0E-5 g/L) (25 ºC)

Related Compounds