Isocryptotanshinone
Names
[ CAS No. ]:
22550-15-8
[ Name ]:
Isocryptotanshinone
[Synonym ]:
4,4,8-Trimethyl-2,3,8,9-tetrahydro-1H,4H-10-oxa-cyclopenta[b]phenanthrene-7,11-dione
Biological Activity
[Description]:
Isocryptotanshinone is a potent signal transducer and activator of transcription 3 (STAT3) and protein tyrosine phosphatase 1B PTP1B inhibitor, with an IC50 of 56.1 μM for PTP1B.
[Related Catalog]:
[Target]
STAT3
PTP1B:56.1 μM (IC50)
[In Vitro]
It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner[1].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H20O3
[ Molecular Weight ]:
296.36000
[ Exact Mass ]:
296.14100
[ PSA ]:
43.37000
[ LogP ]:
3.59990
Safety Information
[ Hazard Codes ]:
Xi