Albendazole Oxide

Names

[ Name ]:
Albendazole Oxide

[Synonym ]:
Rycobendazole
Carbamic acid, N-[5-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester
carbamic acid, N-[6-(propylsulfinyl)-1H-benzimidazol-2-yl]-, methyl ester
MFCD00797922
Albendazole Sulfoxide
Albendazole S-oxide
Ricobendazole
Albendazole sulphoxide
Methyl [5-(propylsulfinyl)-1H-benzimidazol-2-yl]carbamate
Albendazole oxide

Biological Activity

[Description]:

Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Gokhan Adas,, et al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study).

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
357.3ºC at 760 mmHg

[ Melting Point ]:
154-156ºC

[ Molecular Formula ]:
C₁₂H₁₅N₃O₃S

[ Molecular Weight ]:
281.331

[ Flash Point ]:
169.9ºC

[ Exact Mass ]:
281.083405

[ PSA ]:
103.29000

[ LogP ]:
0.91

[ Index of Refraction ]:
1.659

[ Storage condition ]:
-20°C Freezer

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
FD1080000

Precursor & DownStream

Precursor

DownStream

Articles

Azole antifungal inhibition of buprenorphine, methadone and oxycodone in vitro metabolism.

J. Anal. Toxicol. 39 , 374-86, (2015)

Opioid-related mortality rates have escalated. Drug interactions may increase blood concentrations of the opioid. We therefore used human liver microsomes (HLMs) and cDNA-expressed human cytochrome P4...

Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.

Anal. Bioanal. Chem 407 , 4423-35, (2015)

Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the deve...

The transport of albendazole and albendazole sulphoxide in the lancet fluke (Dicrocoelium dendriticum).

Vet. Parasitol. 176(1) , 27-33, (2011)

Albendazole (ABZ) is one of the most important benzimidazole compounds possessing high activity against the lancet fluke, Dicrocoelium dendriticum. ABZ sulphoxide (ABZ.SO) is the main molecule present...