Casein Kinase inhibitor A51 Price from Supplier Brand ShangHai DC Chemicals Co.,Ltd on Chemsrc.com

Published date: 2023-02-17 18:28:52

CAS number: 2079068-74-7

Price:
￥Inquiry/1g

Purity: 98.9%

Stocking period: 1 Day

Stock: In Stock

Detail Product Information:
Casein Kinase inhibitor A51 (CKIα inhibitor A51) is a novel pan-specific CKI (CSNK1) inhibitor (Kd=0.5-20 nM, CKIα Kd=5.3 nM) that co-targets the transcriptional kinases CDK7 and CDK9, with hardly inhibition of CDK8, CDK13, CDK11a, CDK11b, and CDK19; target both CDK7 and CDK9 with low nM Kd values; induces leukemia cell apoptosis at <160 nM, in correlation to the capacity to stabilize p53; shows high and selective sensitivity against leukemic CFUs in colony-forming unit (CFU) assay, without effect on normal hematopoietic CFUs; blocking CKIα together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, induce apoptosis, abolishes the expression of MYC, MDM2, and the anti-apoptotic oncogene MCL1; demonstrates therapeutic efficacy with preserved hematopoiesis and leukemia cure potential in AML mouse models.

Name: ShangHai DC Chemicals Co.,Ltd Recommended

Chemsrc Level: Verified

Product #: 14107

Tel: 58447131

Address: Pudong new area Jin Yu road 100#

Area: China(Mainland)

Contact: Tony Lai

Contact Phone #: 13564518121

Email: order@dcchemicals.com

Website: http://www.biomedgen.cn

Foreign Trade % of Salers: 20%

Major partners:

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D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.

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