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7α,15-Dihydroxydehydroabietic acid

Names

[ CAS No. ]:
155205-64-4

[ Name ]:
7α,15-Dihydroxydehydroabietic acid

[Synonym ]:
(7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-9-hydroxy-7-(1-hydroxy-1-methylethyl)-1,4a-dimethyl-, (1R,4aS,9R,10aR)-

Biological Activity

[Description]:

7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[In Vitro]

7α,15-Dihydroxydehydroabietic acid（3.125-100 μM；24 小时）显着降低 HUVEC 细胞活力[1]。 7α,15-Dihydroxydehydroabietic acid (3.125-6.25 μM; 24 小时) 显着抑制 HUVEC 中血管生成的促进作用。7α,15-Dihydroxydehydroabietic acid 通过下调 VEGF、p-Akt 和 p-ERK 信号通路抑制血管生成[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Significantly decreased HUVEC cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM Incubation Time: 24 hours Result: Human umbilical vein endothelial cells (HUVECs)[1]3.125 μM, 6.25 μM24 hoursShowed downregulation of VEGF, p-Akt and p-ERK in HUVECs.

[References]

[1]. Tae Kyoung Lee, et al. 7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1084-1089.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
511.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H28O4

[ Molecular Weight ]:
332.434

[ Flash Point ]:
277.2±26.6 °C

[ Exact Mass ]:
332.198761

[ LogP ]:
2.84

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.573

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds