Published date: 2020-12-18 22:54:27
CAS number: 1713240-67-5
Name: CM-4620
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/500mg
Purity: 98.0%
Stocking period: 3 Day
Stock: In Stock
Product Webpage: https://www.dcchemicals.com/product_show-CM-4620.html
Detail Product Information:
CM4620 is a selective Orai1 inhibitor, prevents Ca2+ entry in acinar cells. The intravenous administration of CM4620 reduces the severity of acute pancreatitis in the rat, a hitherto untested species. SOCE via STIM1/Orai complexes promotes activation and fibroinflammatory gene expression within pancreatic stellate cells. CM4620 also decreased myeloperoxidase activity and inflammatory cytokine expression in pancreas and lung tissues, fMLF peptide-induced oxidative burst in human neutrophils, and cytokine production in human peripheral blood mononuclear cells (PBMCs) and rodent PaSCs, indicating that Orai1/STIM1 channels participate in the inflammatory responses of these cell types during acute pancreatitis.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 28108
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
Detail introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
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Name: DC Chemicals Limited
Area: China
Price:
$Inquiry/100mg
$Inquiry/250mg
$Inquiry/500mg
Contact: Tony Cao
Product Detail: CM-4620
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