Published date: 2024-07-17 15:06:38
CAS number: 1816331-66-4
Name: GSK864
Price:
$700.0/100mg
$1300.0/250mg
$2600.0/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-GSK864.html
Detail Product Information:
GSK864 is a potent and selective inhibitor of mutant IDH1. GSK864 inhibits IDH1 mutants R132C/R132H/R132G with IC50 values of 9/15/17 nM, respectively, and is moderately selective over wild-type IDH1 and IDH2 mutants/wild-type. Treatment of R132C IDH1 mutant HT-1080 cells for 24 hours with GSK864 results in a dose-dependent reduction of 2-hydroxyglutarate (2-HG), which is not observed with GSK990, a structurally similar compound which is inactive as an IDH1 inhibitor. GSK864 has been shown to be selective in vitro for IDH1 over other classes of proteins (7TMs, ion channels, kinases) and chemoproteomic studies with GSK321, an analog of GSK864, confirm selective binding of IDH1 by this chemical series. GSK864 has a pharmacokinetic profile suitable for in vivo studies.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34963
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$700.0/100mg
$1300.0/250mg
$2600.0/1g
Contact: Yang
Product Detail: GSK864
Name: DC Chemicals Limited
Area: China
Price:
$700.0/100mg
$1300.0/250mg
$2600.0/1g
Contact: Tony Cao
Product Detail: GSK864
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$700.0/100mg
$1300.0/250mg
$2600.0/1g
Contact: Tony Lai
Product Detail: GSK864
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