Trifolirhizin

Names

[ Name ]:
Trifolirhizin

[Synonym ]:
(6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-3-yl β-D-glucopyranoside
β-D-Glucopyranoside, (6aR,12aR)-6a,12a-dihydro-6H-[1,3]dioxolo[5,6]benzofuro[3,2-c][1]benzopyran-3-yl
n1959

Biological Activity

[Description]:

Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM[1]. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

IC50: 506 μM (tyrosinase)[1]

[References]

[1]. Hyun SK, et al. Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis. Biol Pharm Bull. 2008 Jan;31(1):154-8.

[2]. Zhou H, et al. Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots. J Agric Food Chem. 2009 Jun 10;57(11):4580-5.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
658.7±55.0 °C at 760 mmHg

[ Melting Point ]:
142-144ºC

[ Molecular Formula ]:
C₂₂H₂₂O₁₀

[ Molecular Weight ]:
446.404

[ Flash Point ]:
352.2±31.5 °C

[ Exact Mass ]:
446.121307

[ PSA ]:
136.30000

[ LogP ]:
0.75

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.681

[ Storage condition ]:
?20°C

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50

[ Safety Phrases ]:
61-24/25

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
29389090

Related Compounds

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