Tetrahydrodeoxycorticosterone-d3

Names

[ CAS No. ]:
72205-58-4

[ Name ]:
Tetrahydrodeoxycorticosterone-d3

[Synonym ]:
5β-pregnane-3α,21-diol-20-one, 17,21,21-d3
5β-pregnan-3α,21-diol-20-one, 17,21,21-d3

Biological Activity

[Description]:

Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hua-Jun Feng, et al. Comparison of αβδ and αβγ GABA A receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018 Jul;133:289-300.

[3]. Roger F Butterworth. Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities. J Steroid Biochem Mol Biol. 2016 Jun;160:94-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H31D3O3

[ Molecular Weight ]:
337.51

[ Exact Mass ]:
337.27000

[ PSA ]:
57.53000

[ LogP ]:
3.56760

Related Compounds

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