azobenzene-d10

Names

[ Name ]:
azobenzene-d10

[Synonym ]:
2,2,2-trideuterio-1-pentadeuteriophenyl-ethanone
d10-Azobenzene
bis-pentadeuteriophenyl-diazene
perdeuterated acetophenone
Acetophenone-D8 &acetophenone-d6
perdeuterated azobenzene
acetophenone-d8
perdeuteroacetophenone
<2H8>Acetophenone

Biological Activity

[Description]:

Azobenzene-d10 is the deuterium labeled Azobenzene[1]. Azobenzene can be used as an optical trigger for the design and synthesis of a large variety of photoresponsive systems[2][3][4].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Aemissegger A, et al. Synthesis and application of an azobenzene amino acid as a light-switchable turn element in polypeptides. Nat Protoc. 2007;2(1):161-7.

[3]. Renner C, et al. Azobenzene as photoresponsive conformational switch in cyclic peptides. J Pept Res. 2005 Jan65(1):4-14.

[4]. Beharry AA, et al. Azobenzene photoswitches for biomolecules. Chem Soc Rev. 2011 Aug40(8):4422-37.