CCG-271423

Names

[ CAS No. ]:
2750413-88-6

[ Name ]:
CCG-271423

Biological Activity

[Description]:

CCG-271423 is a potent and selective GRK5 inhibitor with IC50 values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+ transience[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[Target]

IC50: 0.0021 μM (GRK5) and 44 μM (GRK5)[1]


[In Vitro]

CCG-271423 (1 μM) does not alter cardiomyocyte contractility and decreases in Ca2+ transience[1].

[References]

[1]. Rowlands R, et, al. Expanding the Arsenal: Development of G-Protein Receptor Kinase 5 Inhibitors Utilizing a Covalent Strategy.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H26N4O3

[ Molecular Weight ]:
466.53

Related Compounds