CCG-203586
Names
[ CAS No. ]:
1430611-24-7
[ Name ]:
CCG-203586
Biological Activity
[Description]:
A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM; inhibits GlcCer production in whole wild-type MDCKII cells with IC50 of 15.3 nM, has little to no apparent recognition by MDR1; significantly and dose-dependently decreases brain glucosylceramide content after intraperitoneal administration in mice.
[References]
References 1. Larsen SD, et al. J Lipid Res. 2012 Feb;53(2):282-91. 2. Arthur JR, et al. Neurochem Res. 2013 Apr;38(4):866-75. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C26H32N2O4
[ Molecular Weight ]:
436.552