FR234938

Names

[ Name ]:
FR234938

[Synonym ]:
1H-Imidazole-4-carboxamide,1-((1R,2S)-2-hydroxy-1-(2-(1-naphthalenyl)ethyl)propyl)
imidazole-4-carboxamide analogue,5
2e1w

Biological Activity

[Description]:

FR234938 is a non-nucleoside adenosine deaminase inhibitor with an IC50 of 17 nM for recombinant human adenosine deaminase enzyme. FR234938 has anti-rheumatic and anti-inflammatory effects[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase

[Target]

IC50: 17 nM (recombinant human adenosine deaminase)[1]

[References]

[1]. Masako Kuno, et al. Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938. Eur J Pharmacol. 2006 Mar 18;534(1-3):241-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁N₃O₂

[ Molecular Weight ]:
323.39

[ Exact Mass ]:
323.16300

[ PSA ]:
82.13000

[ LogP ]:
3.57410

Related Compounds

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