ITK inhibitor 5

Names

[ Name ]:
ITK inhibitor 5

Biological Activity

[Description]:

ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC50s of 5.6, 25 nM for ITK, BTK, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk

[References]

[1]. Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈F₂N₄O₂

[ Molecular Weight ]:
396.39

Related Compounds

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