Z-Leu-Leu-Tyr-α-keto aldehyde

Names

[ CAS No. ]:
204649-66-1

[ Name ]:
Z-Leu-Leu-Tyr-α-keto aldehyde

[Synonym ]:
L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[(4-hydroxyphenyl)methyl]-2,3-dioxopropyl]-
N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(4-hydroxyphenyl)-3,4-dioxo-2-butanyl]-L-leucinamide
MFCD03788098

Biological Activity

[Description]:

Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a Ki value of 3.0 nM[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. Lynas JF, et, al. Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl alpha-keto aldehydes (glyoxals). Bioorg Med Chem Lett. 1998 Feb 17;8(4):373-8.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
813.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H39N3O7

[ Molecular Weight ]:
553.65

[ Flash Point ]:
445.6±34.3 °C

[ Exact Mass ]:
553.278809

[ LogP ]:
4.87

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.552

Related Compounds