CB2R agonist 1

CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role[1].

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

CB2R:0.56 μM (EC50)

CB2R agonist 1 (Compound 4) (1 和 10 μM；24 h) 以浓度依赖性方式增加单核细胞和巨噬细胞中 IL-4、IL-10 抗炎细胞因子的产生，减少 TNF-α、IFN-γ、IL-1β、IL-6 的产生[1]。

[1]. Graziano G, et al. N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R). Eur J Med Chem. 2023 Feb 15;248:115109.