(p-Iodo-Phe7)-ACTH (4-10)

Names

[ Name ]:
(p-Iodo-Phe7)-ACTH (4-10)

[Synonym ]:
Glycine, L-methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophyl-
L-Methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophylglycine

Biological Activity

[Description]:

(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor

[In Vitro]

(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1]. [Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2].

[In Vivo]

(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats[1]. Animal Model: Male Wistar rats (150 g)[1] Dosage: 1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not Administration: Intracerebroventricular injection; one week prior to the experiment Result: Didn’t induce excessive grooming behavior by single dose. Inhibited the induction of excessive grooming behavior by a-MSH.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C₄₄H₅₈IN₁₃O₁₀S

[ Molecular Weight ]:
1087.982

[ Exact Mass ]:
1087.319458

[ LogP ]:
0.85

[ Index of Refraction ]:
1.711

Related Compounds

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