Plasma kallikrein-IN-3

Names

[ CAS No. ]:
1357950-47-0

[ Name ]:
Plasma kallikrein-IN-3

Biological Activity

[Description]:

Plasma kallikrein-IN-3 is a plasma kallikrein inhibitor (IC50: 0.15 μM). Plasma kallikrein-IN-3 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease
Research Areas >> Cardiovascular Disease
Research Areas >> Metabolic Disease

[Target]

Plasma kallikrein[1]


[In Vitro]

Plasma kallikrein-IN-3 (example 13, 1 nM-100 μM, 1 h) inhibits plasma kallikrein activity with an IC<>50 value of 0.15 μM[1].

[References]

[1]. Brandl Trixi, et al. Preparation of N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides as inhibitors of plasma kallikrein. Patent WO2012017020.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H23N5O2

[ Molecular Weight ]:
365.43

Related Compounds