Ibuprofen Acyl-b-D-glucuronide
Names
[ CAS No. ]:
115075-59-7
[ Name ]:
Ibuprofen Acyl-b-D-glucuronide
[Synonym ]:
ibuprofen acyl glucuronide
Ibuprofen Acyl--D-glucuronide
1-[a-Methyl-4-(2-methylpropyl)benzeneacetate]-D-Glucopyranuronic Acid
Ibuprofen Acyl-Beta-D-glucuronide
Ibuprofen glucuronide
Chemical & Physical Properties
[ Density]:
1.34g/cm3
[ Boiling Point ]:
567.3ºC at 760 mmHg
[ Melting Point ]:
26-28ºC
[ Molecular Formula ]:
C19H26O8
[ Molecular Weight ]:
382.40500
[ Flash Point ]:
198.3ºC
[ Exact Mass ]:
382.16300
[ PSA ]:
133.52000
[ LogP ]:
0.42400
[ Vapour Pressure ]:
1.05E-13mmHg at 25°C
[ Index of Refraction ]:
1.581
[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
[ Stability ]:
Hygroscopic, Not stable in aqueous solutions.
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Articles
J. Chromatogr. A. 614(1) , 109-16, (1993)
A method for the simultaneous determination of ibuprofen and its labile, reactive metabolite, ibuprofen acyl glucuronide, in plasma is described. Reversed-phase high-performance liquid chromatography ...
Disposition and reactivity of ibuprofen and ibufenac acyl glucuronides in vivo in the rhesus monkey and in vitro with human serum albumin.Drug Metab. Dispos. 23(5) , 566-72, (1995)
The disposition of ibuprofen and ibufenac, an analog of ibuprofen with a history of severe adverse reactions, was investigated in Rhesus monkeys after oral administration. Plasma concentrations of the...
Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4.J. Pharmacol. Exp. Ther. 356 , 366-74, (2016)
Combined administration of methotrexate (MTX) and nonsteroidal anti-inflammatory drugs (NSAIDs) can result in a decreased systemic clearance of MTX. To date, inhibition of renal uptake via organic ani...