MCHR1 antagonist 3

Names

[ CAS No. ]:
1069622-60-1

[ Name ]:
MCHR1 antagonist 3

Biological Activity

[Description]:

MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24)
Research Areas >> Metabolic Disease

[In Vitro]

Compound 1, derived from a spirohydantoin scaffold, exhibits a Ki of 50 nM at MCH-R1. Compound 1 is a potent inhibitor of CYP3A4 (IC50=35 nM). MCHR1 antagonist 3 is an analog of compound 1[1].

[References]

[1]. Rowbottom MW, et al. Synthesis and structure-activity relationships of spirohydantoin-derived small-moleculeantagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Bioorg Med Chem Lett. 2007 Apr 15;17(8):2171-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H36N4O2

[ Molecular Weight ]:
472.62

Related Compounds