Zonisamide-d4

Names

[ CAS No. ]:
1020720-04-0

[ Name ]:
Zonisamide-d4

[Synonym ]:
Excegran-d4
Zonegran-d4
1,2-(Benzisoxazole-d4)-3-methanesulfonamide
AD 810-d4
Zonisamide-d4
Aleviatin-d4
3-(Sulfamoylmethyl)-1,2-benzisoxazole-d4

Biological Activity

[Description]:

Zonisamide-d4 (AD 810-d4) is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Peters DH, et al. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993 May;45(5):760-87.

[3]. Giuseppina De Simone, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15(9):2315-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H4D4N2O3S

[ Molecular Weight ]:
216.25000

[ Exact Mass ]:
216.05100

[ PSA ]:
94.57000

[ LogP ]:
2.39740

Related Compounds