β2AR/M-receptor agonist-2

Names

[ CAS No. ]:
1017857-38-3

[ Name ]:
β2AR/M-receptor agonist-2

Biological Activity

[Description]:

β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> mAChR
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Inflammation/Immunology

[In Vivo]

β2AR/M-receptor agonist-2 剂量依赖地抑制甲基胆碱诱导的犬支气管收缩，其 ID50 值为 50 mg[1]。

[References]

[1]. Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H49ClN4O7S

[ Molecular Weight ]:
717.31

Related Compounds

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